Discworld: Ankh-Morpork

Yes — whenever you add or move a minion into an area that already has one or more minions (even if they are all yours) you must place a trouble marker there (unless it already has one). (pages 4, 7)

No — you may only assassinate a minion (or troll/demon) in an area that contains a trouble marker. (page 4)

You do not need to control the area — you only need at least one of your minions there, the area must not contain a trouble marker or an existing building, and you pay the area's cost to the bank. (pages 4–5)

No — an interrupt card only protects a single minion; if the attacker has a second assassination symbol they can still attempt to remove another minion unless you play another interrupt. (page 7)

Except for Commander Vimes, all Personality victory conditions must be true at the start of your turn to win; the game can also end immediately if the Riot random event conditions occur or the draw pile is exhausted. (pages 6, 3)

Yes — the Random Event action is mandatory: you must draw the top Random Event card and resolve it (and each Random Event card is used only once). (page 5)