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You roll the six green dice by default, and you may add the yellow die by spending a Common Item or the red die by spending a Unique Item when instructed; the yellow has a 4-investigation face and the red has a wildcard face. (pages 6, 9)

After a failed attempt you first resolve any Terror effects, then you may either set one die aside and try again (optionally focusing or assisting with one die) or choose to fail the Adventure and suffer its penalties; if you cannot possibly complete any remaining tasks you automatically fail. (page 7)

On your Advance the Clock step you turn the clock hand clockwise 3 hours (it will only sit on III, VI, IX, or XII); if the hand reaches XII you resolve any “At Midnight” effects and then draw and resolve a Mythos card. (page 9)

When a locked die icon appears you immediately place a die of that color on the icon and that die cannot be added to rolls, used to complete tasks, or moved until the card/marker is removed or the Adventure resolved; you must place it even if it was on a Spell or Investigator marker. (page 11)

If an investigator’s Sanity or Stamina (or both) is reduced to 0 or less they are devoured: add 1 Doom token, return their card and possessions to the decks/cup, and the player takes a new investigator (if available) who starts full; if no investigators remain the player is out of the game but may still win under some conditions. (page 11)

When the last Doom token is placed the Ancient One awakens immediately, all investigators move to the Ancient One card, and turns change to Attack the Ancient One (complete its combat task to remove Doom) then Advance the Clock, with the Ancient One’s attack replacing Mythos draws at midnight; investigators win by collecting the required Elder Signs or removing the final Doom token, and lose if all are devoured during the final battle. (pages 11–12)