50 Missions

No — you may not state what numbers or colors you have; you may only say which piles to play on or which goal cards to pursue (Communication). (p. 1)

You may play a card if it matches either the top card's color or its number (it can also match both). After playing, draw back up to four cards if the draw pile still has cards. (How to Play / Setup). (p. 1)

Yes — any goal completed by the starting face-up piles is collected into a separate “wins” pile and replaced with new goal cards from the goal pile. (Setup / Notes). (p. 1)

On your turn you play one card, then draw back up to four cards from the draw pile if there are still cards left, so your hand should be refilled to four when possible. (How to Play / Setup). (p. 1)

Yes — if multiple goal cards are completed on a turn, immediately collect all related goal cards, place them in your wins pile, and replace them with new goals from the goal pile. (How to Play / Notes). (p. 1)

You lose if the draw pile runs out and all players are out of cards, or if a player cannot legally play a card before all goals are completed. (Ending the Game). (p. 1)